Sleepless near me8/9/2023 ![]() Note: Altering your dose or discontinuing any of your prescription medications should always be done under the care and supervision of your physician. The bottom line here is that we need to be aware of medications that could potentially create an imbalance in your nutritional status and correct them. 25-27īeta-blocking medications deplete nutrients that are essential to the metabolic activities of every cell in the body. ![]() Melatonin administration typically involves dosages ranging from 500 mcg to 5 mg nightly to promote sleep. Scientific evidence from the last 15 years has suggested that melatonin has positive effects on the cardiovascular system. 24 Melatonin’s universal action on oxidative stress through its scavenging and antioxidant effects plays a role in several metabolic functions influencing virtually every living cell. 23Ĭlinical data indicates melatonin not only plays a significant role in regulating our sleep-wake cycle or circadian rhythms, it also plays a part in protecting against cardiovascular disease, neurological disease, and other diseases related to aging. People with insomnia are also at risk of increased mortality and reduced quality of life and productivity. Persons experiencing sleep insufficiency are also more likely to suffer from chronic diseases such as hypertension, high blood sugar and diabetes, depression, obesity, and cancer. 22ĭepression, Cancer and Obesity: Why Insomnia Is ConcerningĪccording to the Centers for Disease Control and Prevention, insufficient sleep is a public health epidemic. 6,20-21 People with hypertension already have a lower melatonin production rate than those with normal blood pressure. Melatonin is a hormone secreted by the pineal gland in the brain, and helps in maintaining normal circadian rhythms. They have been shown to reduce the production of melatonin via specific inhibition of beta-1 adrenergic receptors. 9īeta-Blockers Side Effect: Insomnia due to Reduced Melatonin Levelsīeta blockers have long been associated with sleep disturbances such as difficulty falling asleep, staying asleep, and insomnia. 19 Based on a meta-analysis of published scientific research, therapeutic doses of ubiquinol range between 100 to 200 mg daily, but may be increased if conditions warrant. 15-18 Ubiquinol (the active form of CoQ10) has a much greater bioavailability than ubiquinone (the oxidized form), helping to improve metabolic efficiency of the cardiovascular system to maintain heart health. While adults over the age of 30 can benefit from taking CoQ10 supplements, they are especially important for people with cardiovascular concerns, and those who take certain blood pressure medications like beta-blockers. Levels of CoQ10 naturally decline with age. Lowered levels of CoQ10 and its role in the pathophysiology of chronic fatigue as a direct result of 10-13 A 2009 clinical study showed a close correlation between CoQ10 is a mitochondrial enzymeĮssential for the production of adenosine triphosphate (ATP), the core of cellular energy 8,9 This drug-inducedĭepletion may be particularly serious in theĮlderly, who already suffer from a natural age-related CoQ10 deficiency. Production and protection against free radicals, contributing to fatigue. This is because beta-blockers decrease the production of CoQ10 (an enzyme needed in energy production) and affect melatonin levels (the sleeping hormone).īeta-Blocker Side Effect: Fatigue Symptoms due to CoQ10 Deficiencyīeta-blockers have been shown to block the biological pathway of coenzyme Q10-dependent enzymes in the Beta-blockers are some of the most commonly prescribed and effective medications for lowering blood pressure, however a negative consequence is that they may negatively impact energy and sleep, leading to symptoms of fatigue and even insomnia. 5-7īeta Blocker Side Effects: Fatigue Symptoms, InsomniaĪmericans are in dire need of blood pressure control, as approximately one in three adults is currently living with hypertension. 3,4 Common side effects associated with the use of this medication include symptoms of fatigue as well as sleep disturbances including insomnia. Unfortunately, these changes, including the slowed heart rate, can lead to adverse side effects since beta-receptors affect multiple metabolic and physiologic functions. ![]() This in turn slows the heart rate, relaxes blood vessels, and improves conduction signals in the heart, thereby lowering blood pressure. Beta-blockers, also known as beta-adrenergic blocking agents, reduce the effects of catecholamines (norepinephrine and epinephrine, the fight-or-flight hormones). Why is this and what can I do?Ī: Atenolol is a beta-blocker commonly prescribed for patients with cardiovascular disease and hypertension (high blood pressure). Ever since I started taking it, I constantly feel fatigued and lethargic, yet at night I don’t get any restful sleep. Q: My doctor prescribed atenolol ( Tenormin®) to treat my high blood pressure.
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